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Total-body photography (TBP) has the potential to revolutionize early detection of skin cancers by monitoring minute changes in lesions over time. However, there is no standardized Digital Imaging and Communications in Medicine (DICOM) format for TBP. In order to accommodate various TBP data types and sophisticated data preprocessing pipelines, we propose three TBP Extended Information Object Definitions (IODs) for 2D regional images, dermoscopy images, and 3D surface meshes. We introduce a comprehensive pipeline integrating advanced image processing techniques, including 3D DICOM representation, super-resolution enhancement, and style transfer for dermoscopic-like visualization. Our framework tracks individual lesions across multiple TBP scans from different imaging systems and provides cloud-based storage with a customized DICOM viewer. To demonstrate the effectiveness of our approach, we validate our framework using TBP datasets from multiple imaging systems. Our framework and proposed IODs enhance TBP interoperability and clinical utility in dermatological practice, potentially improving early skin cancer detection. 

Abstract CUPID, the CUORE Upgrade with Particle Identification, is a next-generation experiment to search for neutrinoless double beta decay ($$0\mathrm {\nu \beta \beta }$$ $0\nu \beta \beta$) and other rare events using enriched Li$$_{2}$$ $_2^{}$$$^{100}$$ $_{}^{100}$MoO$$_{4}$$ $_4^{}$scintillating bolometers. It will be hosted by the CUORE cryostat located at the Laboratori Nazionali del Gran Sasso in Italy. The main physics goal of CUPID is to search for$$0\mathrm {\nu \beta \beta }$$ $0\nu \beta \beta$of$$^{100}$$ $_{}^{100}$Mo with a discovery sensitivity covering the full neutrino mass regime in the inverted ordering scenario, as well as the portion of the normal ordering regime with lightest neutrino mass larger than 10 meV. With a conservative background index of 10$$^{-4}$$ $_{}^{-4}$ cts$$/($$ $/($keV$$\cdot $$ $·$kg$$\cdot $$ $·$yr$$)$$ $)$, 240 kg isotope mass, 5 keV FWHM energy resolution at 3 MeV and 10 live-years of data taking, CUPID will have a 90% C.L. half-life exclusion sensitivity of$$1.8\cdot 10^{27}$$ $1.8·{10}^{27}$ yr, corresponding to an effective Majorana neutrino mass ($$m_{\beta \beta }$$ $m_{\beta \beta }$) sensitivity of 9–15 meV, and a$$3\sigma $$ $3\sigma$discovery sensitivity of$$1\cdot 10^{27}$$ $1·{10}^{27}$ yr, corresponding to an$$m_{\beta \beta }$$ $m_{\beta \beta }$range of 12–21 meV. 

Abstract An array of twelve 0.28 kg lithium molybdate (LMO) low-temperature bolometers equipped with 16 bolometric Ge light detectors, aiming at optimization of detector structure for CROSS and CUPID double-beta decay experiments, was constructed and tested in a low-background pulse-tube-based cryostat at the Canfranc underground laboratory in Spain. Performance of the scintillating bolometers was studied depending on the size of phonon NTD-Ge sensors glued to both LMO and Ge absorbers, shape of the Ge light detectors (circular vs. square, from two suppliers), in different light collection conditions (with and without reflector, with aluminum coated LMO crystal surface). The scintillating bolometer array was operated over 8 months in the low-background conditions that allowed to probe a very low, μBq/kg, level of the LMO crystals radioactive contamination by 228 Th and 226 Ra. 

Abstract CUPID is a next-generation bolometric experiment aiming at searching for neutrinoless double-beta decay with ∼250 kg of isotopic mass of 100 Mo. It will operate at ∼10 mK in a cryostat currently hosting a similar-scale bolometric array for the CUORE experiment at the Gran Sasso National Laboratory (Italy). CUPID will be based on large-volume scintillating bolometers consisting of 100 Mo-enriched Li 2 MoO 4 crystals, facing thin Ge-wafer-based bolometric light detectors. In the CUPID design, the detector structure is novel and needs to be validated. In particular, the CUORE cryostat presents a high level of mechanical vibrations due to the use of pulse tubes and the effect of vibrations on the detector performance must be investigated. In this paper we report the first test of the CUPID-design bolometric light detectors with NTD-Ge sensors in a dilution refrigerator equipped with a pulse tube in an above-ground lab. Light detectors are characterized in terms of sensitivity, energy resolution, pulse time constants, and noise power spectrum. Despite the challenging noisy environment due to pulse-tube-induced vibrations, we demonstrate that all the four tested light detectors comply with the CUPID goal in terms of intrinsic energy resolution of 100 eV RMS baseline noise. Indeed, we have measured 70–90 eV RMS for the four devices, which show an excellent reproducibility. We have also obtained high energy resolutions at the 356 keV line from a 133 Ba source, as good as Ge semiconductor γ detectors in this energy range. 

Abstract CUORE Upgrade with Particle IDentification (CUPID) is a foreseen ton-scale array of Li 2 MoO 4 (LMO) cryogenic calorimeters with double readout of heat and light signals. Its scientific goal is to fully explore the inverted hierarchy of neutrino masses in the search for neutrinoless double beta decay of 100 Mo. Pile-up of standard double beta decay of the candidate isotope is a relevant background. We generate pile-up heat events via injection of Joule heater pulses with a programmable waveform generator in a small array of LMO crystals operated underground in the Laboratori Nazionali del Gran Sasso, Italy. This allows to label pile-up pulses and control both time difference and underlying amplitudes of individual heat pulses in the data. We present the performance of supervised learning classifiers on data and the attained pile-up rejection efficiency. 

Abstract CUPID will be a next generation experiment searching for the neutrinoless double $$\beta $$ β decay, whose discovery would establish the Majorana nature of the neutrino. Based on the experience achieved with the CUORE experiment, presently taking data at LNGS, CUPID aims to reach a background free environment by means of scintillating Li $$_{2}$$ 2 $$^{100}$$ 100 MoO $$_4$$ 4 crystals coupled to light detectors. Indeed, the simultaneous heat and light detection allows us to reject the dominant background of $$\alpha $$ α particles, as proven by the CUPID-0 and CUPID-Mo demonstrators. In this work we present the results of the first test of the CUPID baseline module. In particular, we propose a new optimized detector structure and light sensors design to enhance the engineering and the light collection, respectively. We characterized the heat detectors, achieving an energy resolution of (5.9 ± 0.2) keV FWHM at the Q -value of $$^{100}$$ 100 Mo (about 3034 keV). We studied the light collection of the baseline CUPID design with respect to an alternative configuration which features gravity-assisted light detectors’ mounting. In both cases we obtained an improvement in the light collection with respect to past measures and we validated the particle identification capability of the detector, which ensures an $$\alpha $$ α particle rejection higher than 99.9%, fully satisfying the requirements for CUPID. 

Abstract The Murchison Widefield Array (MWA) is an open access telescope dedicated to studying the low-frequency (80–300 MHz) southern sky. Since beginning operations in mid-2013, the MWA has opened a new observational window in the southern hemisphere enabling many science areas. The driving science objectives of the original design were to observe 21 cm radiation from the Epoch of Reionisation (EoR), explore the radio time domain, perform Galactic and extragalactic surveys, and monitor solar, heliospheric, and ionospheric phenomena. All together $60+$ programs recorded 20 000 h producing 146 papers to date. In 2016, the telescope underwent a major upgrade resulting in alternating compact and extended configurations. Other upgrades, including digital back-ends and a rapid-response triggering system, have been developed since the original array was commissioned. In this paper, we review the major results from the prior operation of the MWA and then discuss the new science paths enabled by the improved capabilities. We group these science opportunities by the four original science themes but also include ideas for directions outside these categories.